College of Pharmacy

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JiazhiSun

Jiazhi Sun, M.D.

Assistant Professor, Cop Dept Of Pharmaceutical Science

Cop Dept Of Pharmaceutical Science

Contact Info 12901 Bruce B. Downs Blvd.
3027A MDC30
Tampa, FL 33612

Academic Email: jsun@health.usf.edu

Academic Phone: (813) 974-7468

Education

  • MS, West Virginia University, 1994
  • MBBS, Beijing Medical University, 1986

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology
  • Cardiovascular

Research Interests

  • Dr. Jiazhi Sun has been trained in the field of basic medical science and molecular biology and received M.D. degree from Peking University in 1986. After completing his residency and fellowship training at Peking University in 1990 and graduate studies on targeting Q-binding protein into yeast mitochondria at West Virginia University in 1994, he received two-terms postdoc training at the University of Pittsburgh and H. Lee Moffitt Cancer Center in the field of Pharmacology, Biochemistry and Drug Discovery from 1994 to 2003. He currently holds joint Assistant Professor of Department of Pharmaceutical Sciences of College of Pharmacy and Department of Molecular Medicine of Morsani College of Medicine at University of South Florida. His research focuses on Ras and ER signaling study, HDL-Receptor RNA alternative processing, and K-Ras, GPCR, BH3 protein and VDR/ER drug discovery targeting by utilizing Target-Guided Synthesis (TGS) approach and conventional intervention. Dr. Sun has more than 15-year professional experience in academic field including Drug Discovery, Signal Transduction, Apoptosis, Cancer Biology and Cardiovascular field, also leading collaborative Institutional and Pharmaceutical Industry rational design/targeted-therapeutic approach and development of FTI, GGTI and Kinase inhibitors (tyrosine, serine/threonine and sphingosine) and nuclear hormone receptor mimics as well as BH3-mimics as drug candidates and “Chemical-Genetics” tool/model. Since 1994, he has been involved in multiple programs yielding two U.S. patents, more than 30 peer-reviewed papers, book chapter, numerous awards including AFLAC Scholar in Cancer Research Award sponsored by American Association of Cancer Research and more than 30 scientific professional presentations.

Memberships

  • American Association of Colleges of Pharmacy (Member, 2012 - Present)
  • National Academy of Inventors (Member, 2012 - Present)
  • American Chemical Society (Member, 2004 - Present)
  • American Association for Cancer Research (Active member, 1995 - Present)
  • American Association for Advancement of Science (Member, 1991 - Present)

Recent Publications

  • Kazi, A.Sun, J.Doi, K.Sung, SS.Takahashi, Y.Yin, H.Rodriguez, JM.Becerril, J.Berndt, N.Hamilton, AD.Wang, HG.Sebti, SM. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of biological chemistry. 286(11) : 9382-92, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21148306
  • Wei, J.Kitada, S.Rega, MF.Emdadi, A.Yuan, H.Cellitti, J.Stebbins, JL.Zhai, D.Sun, J.Yang, L.Dahl, R.Zhang, Z.Wu, B.Wang, S.Reed, TA.Wang, HG.Lawrence, N.Sebti, S.Reed, JC.Pellecchia, M. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Molecular cancer therapeutics. 8(4) : 904-13, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19372563
  • Hu, X.Sun, J.Wang, HG.Manetsch, R. Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides. Journal of the American Chemical Society. 130(42) : 13820-1, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18811158
  • Sun, J.Wang, DA.Jain, RK.Carie, A.Paquette, S.Ennis, E.Blaskovich, MA.Baldini, L.Coppola, D.Hamilton, AD.Sebti, SM. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 24(29) : 4701-9, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15897913
  • Sun, J.Blaskovich, MA.Jove, R.Livingston, SK.Coppola, D.Sebti, SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. 24(20) : 3236-45, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15735720
  • Sun, J.Blaskovich, MA.Jain, RK.Delarue, F.Paris, D.Brem, S.Wotoczek-Obadia, M.Lin, Q.Coppola, D.Choi, K.Mullan, M.Hamilton, AD.Sebti, SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer research. 64(10) : 3586-92, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15150116
  • Jiang, K.Sun, J.Cheng, J.Djeu, JY.Wei, S.Sebti, S. Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Molecular and cellular biology. 24(12) : 5565-76, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15169915
  • Paris, D.Townsend, K.Quadros, A.Humphrey, J.Sun, J.Brem, S.Wotoczek-Obadia, M.DelleDonne, A.Patel, N.Obregon, DF.Crescentini, R.Abdullah, L.Coppola, D.Rojiani, AM.Crawford, F.Sebti, SM.Mullan, M. Inhibition of angiogenesis by Abeta peptides. Angiogenesis. 7(1) : 75-85, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15302999
  • Dasgupta, P.Sun, J.Wang, S.Fusaro, G.Betts, V.Padmanabhan, J.Sebti, SM.Chellappan, SP. Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Molecular and cellular biology. 24(21) : 9527-41, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15485920
  • Sun, J.Ohkanda, J.Coppola, D.Yin, H.Kothare, M.Busciglio, B.Hamilton, AD.Sebti, SM. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer research. 63(24) : 8922-9, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14695209

Awards/Honors

  • AFLAC Scholar in Cancer Research Award (AACR - 1999)