College of Pharmacy

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Siva KumarPanguluri

Siva Kumar Panguluri, Ph.D

Assistant Professor, Cop Dept Of Pharmaceutical Science

Cop Dept Of Pharmaceutical Science

Assistant Professor, Pharmaceutical Sciences, University of South Florida

Academic Email: spangulu@health.usf.edu

Academic Phone: (813) 974-6571

View My C.V.

Education

  • PhD, Biotechnology, Ch Charan Singh University, 2006
  • PhD, Biotechnology, Ch.Ch.Singh University, 2006

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cancer Biology
  • Cardiovascular
  • Cardiovascular Sciences
  • Cellular and Molecular Biology
  • Neuroscience

Research Interests

  • Research projects under investigation:
  • 1. Molecular mechanisms underlying learning-dependent modulation of ingestive behavior. Main goal of this project is to understand the complete mechanisms of the molecular events (e.g. networks of genes) in the brain (e.g. networks of neurons) that underlie hedonic coding, which will make it possible to pharmacologically increase the palatability of less caloric dense foods (e.g. low sugar/low fat).
  • 2. Ventricular and electrical remodeling of heart under hyperoxia-induced stress or metabolic disorder such as Diabetes.
  • 3. Establishing Pharmacogenomics for the FDA approved drugs and implication of personalized medicine for better patient outcome.

Memberships

  • AHA (Professional Member, 2011 - Present)
  • SFN (Member, 2009 - Present)
  • AChems (Member, 2009 - Present)

Recent Publications

  • Panguluri SK, Tur J, Fukumoto J, Deng W, Sneed KB, Kolliputi N, Bennett ES, Tipparaju SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12) : H1651-61, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23585127
  • Panguluri SK, Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Tipparaju SM. MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators. PloS one. 8(4) : e60545, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23573265
  • Panguluri SK, Kakar SS. Using quantitative real-time reverse transcriptase polymerase chain reaction to validate gene regulation by PTTG. Methods in molecular biology (Clifton, N.J.). 815: 131-45, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22130989
  • Bhatnagar S, Panguluri SK, Kumar A. Gene profiling studies in skeletal muscle by quantitative real-time polymerase chain reaction assay. Methods in molecular biology (Clifton, N.J.). 798: 311-24, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22130845
  • Panguluri SK, Kuwabara N, Kang Y, Cooper N, Lundy RF. Conditioned taste aversion dependent regulation of amygdala gene expression. Physiology & behavior. 105(4) : 996-1006, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22119580
  • Kumar S, Kumar A, Shah PP, Rai SN, Panguluri SK, Kakar SS. MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines. Journal of ovarian research. 4(1) : 17, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21939554
  • Paul PK, Gupta SK, Bhatnagar S, Panguluri SK, Darnay BG, Choi Y, Kumar A. Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. The Journal of cell biology. 191(7) : 1395-411, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21187332
  • Bhatnagar S, Panguluri SK, Gupta SK, Dahiya S, Lundy RF, Kumar A. Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells. PloS one. 5(10) : e13262, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20967264
  • Panguluri SK, Bhatnagar S, Kumar A, McCarthy JJ, Srivastava AK, Cooper NG, Lundy RF, Kumar A. Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice. PloS one. 5(1) : e8760, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20098732
  • Pathan FK, Venkata DA, Panguluri SK. Recent patents on antimicrobial peptides. Recent patents on DNA & gene sequences. 4(1) : 10-6, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20218955
  • Panguluri SK, Kakar SS. Effect of PTTG on endogenous gene expression in HEK 293 cells. BMC genomics. 10: 577, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19958546
  • Panguluri SK, Yeakel C, Kakar SS. PTTG: an important target gene for ovarian cancer therapy. Journal of ovarian research. 1(1) : 6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19014669
  • Panguluri SK, Li B, Hormann RE, Palli SR. Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells. The FEBS journal. 274(21) : 5669-89, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17922837
  • Panguluri SK, Kumar P, Palli SR. Functional characterization of ecdysone receptor gene switches in mammalian cells. The FEBS journal. 273(24) : 5550-63, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17096690
  • Panguluri SK, Sridhar J, Jagadish B, Sharma PC, Kumar PA. Isolation and characterization of a green tissue-specific promoter from pigeonpea [Cajanus cajan (L.) Millsp.]. Indian journal of experimental biology. 43(4) : 369-72, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15875723
  • Bhalla R, Dalal M, Panguluri SK, Jagadish B, Mandaokar AD, Singh AK, Kumar PA. Isolation, characterization and expression of a novel vegetative insecticidal protein gene of Bacillus thuringiensis. FEMS microbiology letters. 243(2) : 467-72, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15686851

Positions Held

  • Research Associate (Pharmaceutical Sciences, University of South Florida 2011 - 2013)
  • Instructor (Anatomical Sciences and Neurobiology, University of Louisville 2008 - 2011)
  • Post Doctoral (Entamology, University of Kentucky 2005 - 2008)
  • Post Doctoral (Medicine, University of Louisville 2007 - 2008)

Awards/Honors

  • Fellow of Association of Biotechnology and Pharmacy (ABAP - 2009)