Research Interest

• Fundamental changes in aging brain and age related neurological disorders
• Role of astrocytes and microglial cells in the brains reaction to injury .
• Development of animal models for age-related neurodegenerative disorders, such as Alzheimer's and Parkinson's disease
• Identification of the mechanisms leading to neuron loss in neurodegenerative disorders.
• Testing of therapeutic agents addressing the mechanisms of neurotoxicity in age-related neurodegenerative disorders

For more information please visit our Laboratory website at:

http://www.hsc.usf.edu/nocms/medicine/pharmacology/dm/ADRLwebsite/ADRLFrameSet.htm

Recent Publications

Wilcock, D.M., Munireddy, S.K., Rosenthal, A.,  Ugen, K.E., Gordon, M.N. and Morgan, D. (2004). Microglial activation facilitates AB plaque removal following intracranial anti-AB antibody administration . Neurobiology of Disease 15:11-20.

Dickey,C.A., Gordon,M.N.,  Mason, J.E.,  Wilson, N.J. Diamond, D.M., Guzowski, J.M. and Morgan,D. (2004). Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice . Journal of Neurochemistry 88:434.

Li, Q., C Cao, B Chackerian, J Schiller, M Gordon, KE Ugen and D Morgan (2004). Overcoming antigen masking of anti-Aß antibodies reveals breaking of B cell tolerance in Aß immunized amyloid precursor protein transgenic mice .  BMC Neuroscience, 5:19

Wilcock, D., A. Rojiani, A. Rosenthal, J. Alamed, D. Wilson, N. Wilson, M. Freeman, M. Gordon, D. Morgan (2004). Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition . Journal of Neuroscience, 24:6144-6151

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