Paul Shapshak PhD

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Biographical Sketch

Areas of Expertise

• Infectious diseases and International Medicine
• Drug abuse, HIV and HCV risk, and AIDS progression
• Prevention of spread of viruses and AIDS
• Gene expression in neuropsychiatric disease: NeuroAIDS, Alzheimer’s disease
• siRNA and vectors in Biology and Medicine
• Nanotechnology in Biology and Medicine
• Bioinformatics, development of databases, and network analyses of Gene Expression in disease
• Laboratory measures of virus infections, NeuroAIDS, Alzheimer’s disease
• Transmission model and inactivation of HIV-1 and HCV
• HIV-1 and HCV replication and evolution

Current Research

Principal Investigator

Shapshak P (PI), McCoy C, Duncan R, et al. 
Cocaine/cocaethylene/HIV in African-American women.
07/15/1992 – 06/30/1998. RO1 Basic Research Grant, (NIDA.)

Shapshak P (PI), et al.
Replication of HIV in brain cell cultures
9/1/1993-8/31/1999, RO1 Basic Research Grant, renewed, (NIDA.)

Shapshak P (PI), Fenjves E, and Pastori R.
Ribozyme-AAV Targeted Presenilin-1 Reduction in Neurons
10/1/01-9/30/02 RO3 Basic Research Grant (NIA)

Shapshak P (PI)
Gene Expression in HIV Associated Dementia Brain
7/17/02-8/30/05. R21 Basic Research Grant (NIDA.)

Shapshak P, PI (Sub-contract)  
Bioinformatics in Neurodegenerative disease 
The parent grant PI is Dr. T. Kazic, Dept. of Computer Engineering and Computer Science, Univ. of Missouri, Columbia.
Community Deposit and Review of Biochemical Databases 
9/1/2003-8/31/2008 RO1 Research Grant, (2RO1 GM056529 NIGMS)

Shapshak P (PI), Xu W (Co-PI)
siRNA HIV-1B Silencing in NeuroAIDS Patients
Pilot Grant from the Allergy, Immunology & Infectious Disease Signature Program, USF Health.
4/1/2008-3/31/2009

Co-Principal Investigator

McCoy CB (PI) and Shapshak P (Virology/Immunology Core Director)
HIV/Risk reduction within Drug Injecting Networks
6/1/95-5/31/98. RO1 Research Grant, (NIDA.)

Petito C (PI) and Shapshak P, et al,
Neuropathogenesis of HIV encephalitis
9/1/96-8/31/01. RO1 Research Grant, (NINDS.)

Goodkin, K. (Principal Investigator), Shapshak, P, et al.
The impact of a bereavement support group for women with HIV infection,
4/1/97-3/31/02, RO1 Research Grant, (NIMH.)

Weiss S. [PI] and Shapshak P (Virology Director)
Behavioral interventions for women with AIDS
12/1/97-6/30/99, supplement to RO1 Research Grant (NIMH)

Goodkin, K. (Principal Investigator), Shapshak, P, et al.
 AIDS and Aging: indexes of progression,
 8/1/98-7/31/03, RO1 Research Grant, (NIMH.)

Petito C (PI) and Shapshak P, et al,
HIV Brain Sanctuary
9/1/99-8/31/04. RO1 Research Grant, (NINDS)

Kumar M (PI) and Shapshak P, et al,
AIDS in India: HIV-1 and HIV-2.
9/1/01-12/31/02. RO1 Research  Grant (NINDS)

Page JB(PI) and Shapshak P (Co-PI), et al,
HIV Infection Potential in IDU-related injection materials
7/1/00-6/30/04. RO1 Research Grant, (NIDA.)

Goodkin K. (Principal Investigator), Shapshak, P, et al.
AIDS and Aging: indexes of progression,
8/1/04-10/31/04, RO1 Research Grant, (NIMH.)

Colón, HM PhD (Principal Investigator), Shapshak P (Consultant)
Drug Preparation Materials to Reduce HIV/HCV Transmission 
8/15/2005 thru 11/1/2006, 1 R21 DA018600

Eddy Rios-Olivares, PhD, MPH. (Principal Investigator), Shapshak P (Consultant)
HIV and Substances of Abuse 
08/01/2004 thru 11/1/2006   2G12RR03035

Selected Publications

Shapshak P, Fujimura RK, Page JB, Segal D, Yang J, Shah SM, Graham G, Rivers JE, Chitwood DD, and McCoy CB, HIV-1 RNA load in needle/syringes from shooting galleries in Miami: a preliminary laboratory report, Drug and Alcohol Dependence, 58, 153-157, 2000. 

Shapshak P, Fujimura RK, Srivastava A, Goodkin K, Dementia and the Neurovirulence of HIV-1, CNS Spectrums (An International Psychiatry Journal), 5, 31-42, 2000. 

Goodkin, K., Baldewicz, T. T., Wilkie, F. L., Tyll, M. D., & Shapshak, P. HIV-1 infection of the brain: A region-specific approach to its neuropathophysiology and therapeutic aspects. Psychiatric Annals, 31(3), 182-192, 2001.

Goodkin, K., Baldewicz, T. T., Asthana, D., Khamis, I., Blaney, N. T., Kumar, M., Burkhalter, J. E., Leeds, B., & Shapshak, P. A bereavement support group intervention affects plasma burden of HIV-1: Report of a randomized controlled trial. Journal of Human Virology, 4(1), 44-54, 2001.

Goodkin K, Wilkie FL, Concha M, Hinkin CH, Symes S, Baldewicz TT, Asthana D, Fujimura RK, Lee D, van Zuilen MH, Khamis I, Shapshak, P, and Eisdorfer C, Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortality, J of Clin Epidemiology, 54, S35-S43, 2001.

Shapshak P, Torres-Munos J, and Petito CK, Bioinformatics in Neurodegenerative Diseases, Proc. Virt. Conf. Genom. and Bioinf, www.ndsu/virtual-genomics, North Dakota State University, 2001.

Shapshak P, PhD and Stengel R, Discovering Brain Mechanisms and the rules of Molecular Biology, 6th World Multiconference on Systemics, Cybernetics and Informatics, www.iiis.org/sci2002/ Orlando, FL, July 14-18, 2002.

Shapshak, P, Duncan, R, Torres-Munoz JE, Minagar A, and Petito CK, Preliminary Gene Expression Studies in AIDS: Problems and Solutions, Proc. 2nd Virt. Conf. Genom. and Bioinformatics, www.ndsu.edu/virtual-genomics, North Dakota State University, USA. 2002.

Minagar, A., Shapshak, P., Fujimura, R., Ownby, R., Heyes, M., & Eisdorfer, C. The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. Journal of the Neurological Sciences, 202(1-2), 13-23, 2002.

Kuljis RO, Shapshak P, Rodriguez de la Vega P, Fujimura R, and Petito C, Increased density of Neurons containing NADPH diaphorase/nitric oxide synthase in the cerebral cortex of patients with drug abuse and HIV-1 infection, J of NeuroAIDS, 2, 19-36, 2003.

Shapshak P, Stewart RV, Rodriguez de la Vega P, Dominguez B. Fujimura R, Segal DM, Sun NCJ, Delgado S, Petito C, Brain macrophage surface marker expression with HIV-1 infection and drug abuse: a preliminary study, J of NeuroAIDS, 2, 37-50, 2003.

Shapshak P, R Duncan, A Nath, J Turchen, W Davis, EM Duran, F Ziegler, A Minagar, R Seth,  T Kazic, Gene Expression in Human brain and Cultured Human Neurons Exposed to cocaine and HIV-1 proteins gp120 and tat,

Seth R, Shapshak P, Kazic T, Building Models of Biological Domains,

Seth R, Shapshak P, Kazic T, Inferring networks from biological intuition,
   92-94 at the 8th World Multiconf on Systematics, Cybernetics, and Informatics, July 18-21st, 2004, Orlando, Florida. [SCI2004]

Shapshak P, Duncan D, Minagar D, Rodriguez de la Vega P, Stewart R, Petito CK, Elevated expression of IFN-? in the HIV-1 infected brain, Frontiers in Bioscience, 9, 1073-1081, 2004.

Shapshak, P, Duncan, R, Torres-Munoz JE, Duran EM, Minagar A, and Petito CK, Analytic approaches to differential Gene Expression in AIDS vs. Control Brains, Frontiers in Bioscience, 9, 2935-2946, 2004.

McCoy Clyde B, Lisa R. Metsch, Fernando Collado-Mesa, Kristopher L. Arheart, Sarah E. Messiah, Dolores Katz,  Paul Shapshak, The prevalence of HCV and HIV among injection drug users who use high risk inner-city locales in Miami, Florida, Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, 99, 789-793, 2004.

Minagar A, Shapshak P, Duran EM, Kablinger AS, Alexander JS, Kelley RE, Seth R, and Kazic T, Gene expression in HIV-Associated Dementia, Alzheimer’s disease, Multiple Sclerosis, and Schizophrenia, J Neurological Sciences, 224, 3-17, 2004.

Shapshak P, Duncan R, McCoy CB, Page JB, Real Time Reverse Transcriptase PCR Method for Quantification of HIV gag RNA, Frontiers in Bioscience, 10, 135-142, 2005.

Kangueane Pandjassarame, Meena Kishore Sakharkar, Ganapathy Rajaseger, Subhashini Bolisetty, Balasubramanian Sivasekari, Bing Zhao, Manickam Ravichandran, Paul Shapshak, and Subramanian Subbiah, A Framework To Sub-Type HLA Supertypes, Frontiers in Bioscience 10, 879-886, January 1, 2005.

Fujimura Robert K, Imad Khamis, Paul Shapshak, and Karl Goodkin.  Regional quantitative comparison of Multispliced to Unspliced ratios of HIV-1 RNA copy number in infected human brain. Journal of Neuro-AIDS, 2, 45-60, 2005.

Duran, Elda M, Paul Shapshak, Jason Worley, Fabiana Ziegler, Shannon Haliko, Irina Moleon-Borodowsky, and Patrick Haslett, Presenilin-1 Detection In Brain Neurons And Foxp3 In Peripheral Blood Mononuclear Cells: Normalizer Gene Selection For Real Time Reverse Transcriptase PCR Using The ??Ct Method, Frontiers in Biosciences, 10, 2955-2965, 2005

Li L, Gunasekraran K, Gan JG, Zhanhua C, Shapshak, P, Sakharkar MK, and Kangueane P, Structural features differentiate the mechanism between 2S (s state) and S (3 state) folding of homodimers, Bioinformation, 1, 42-49, 2005

Sakharkar MK, Chow VTK, Chaturvedi I, Mathura VS, Shapshak P, Kangueane P, A report on single exon genes (SEG) in eukaryotes. Frontiers in Bioscience, 9, in press, 2006.

Lee D, Karl Goodkin, Robert Lecusay, Paola Suarez, Deshratn Asthana, Paul Shapshak, Rosa Rebecca Molina, and Wenli Zheng, Grief Counseling for Patients with HIV-1 Infection, AIDS Reader, in press, 2006.

Goodkin K, Paul Shapshak, Deshratn Asthana, Wenli Zheng, Mauricio Concha, Frances L. Wilkie, Molina R, Diana Lee, Paola Suarez, Stephen Symes, and Imad Khamis, Older Age and Plasma Viral Load in HIV-1 Infection, AIDS, in press, 2006.

Chiappelli F, Shapshak P, Fariba Younai, McCoy C, Bryan Page, Palo Prolo, Cellular immunopathology in alcohol/cocaine co-abusing HIV-1 seropositive African American Women, Frontiers in Biosciences, 11, 2434-2441, 2006.

Duncan, Robert, Paul Shapshak, J. Bryan Page, Francesco Chiappelli, Sarah E. Messiah, and Clyde B. McCoy, Crack Cocaine: Effect modifier of RNA viral load and CD4 count in HIV infected African American women, Frontiers in Biosciences, 12, 1488-1495, 2006.

Weatherby Norman L., Minsoo Kang, Paul Shapshak, Clyde B. McCoy, Francesco Chiappelli, Screening women for Human Immunodeficiency Virus (HIV) infection using self-reported symptoms: A classification tree analysis, The Korean Journal of Measurement and Evaluation in Physical Education and Sports Science, Vol. 8, No 1, 1-15. July 2006

Shapshak Paul, Robert Duncan, Avindra Nath, Jadwiga Turchan, Pandjassarame Kangueane, Hector Rodriguez, E. Margarita Duran, Fabiana Ziegler, Eric Amaro, Apple Lewis, Alejandro Rodriguez, Alireza Minagar, Wade Davis, Raman Seth, Francesco Chiappelli, and Toni Kazic, Gene Chromosomal Organization and Expression in Cultured Human Neurons Exposed to Cocaine and HIV-1 proteins gp120 and tat: Drug Abuse and NeuroAIDS, Frontiers in Biosciences, 11, 1774-1793, 2006.

Shapshak Paul, Robert Duncan, Jadwiga Turchan, Avindra Nath, Alireza Minagar, Pandjassarame Kangueane, Wade Davis, Francesco Chiappelli, Fatten Elkomy, Raman Seth, Toni Kazic, Bioinformatics Models In Drug Abuse And NeuroAIDS: Using And Developing Databases, Bioinformation, 1 (3), 86-88, 2006.

Ríos-Olivares Eddy, Luis M. Vilá, Juan C. Reyes, José W. Rodríguez, J., Héctor M. Colón, Nat O. Pagán, Amalia Marrero, Zilka M. Ríos-Orraca, Nawal M. Boukli, Paul Shapshak, Rafaela R. Robles, Impaired cytokine production and suppressed lymphocyte proliferation activity in HCV-infected cocaine and heroin (“speedball”) users, Drug & Alcohol Dependence, 85, 236-243, 2006.

Goodkin K, O’Mellan S, Lee D, Asthana D, Molina R, b P, Zheng W, Khamis I, Frasca A, Complicated bereavement: disease state or state of being? Omega: Journal of Death & Dying, 52, 21-36, 2006.

Page J. Bryan, Paul Shapshak, E. Margarita Duran, Gaelle Even, Irina Moleon-Borodowski, Renee Llanusa-Cestero, Detection of HIV-1 in Injection Paraphernalia: Risk in an Era of Heightened Awareness, AIDS Patient Care and STDs, 20, 576-585, 2006.

Goodkin K, B Vitiello, W Lyman, D Asthana, J Atkinson, P Heseltine,  R Molina, W Zheng, I Khamis, F Wilkie, and P Shapshak, CSF and Peripheral HIV Type1 Load in a Multi-Site, Randomized, Double Blind, Placebo-Controlled Trial of D-Ala1-Peptide T-Amide (DAPTA) for Associated Cognitive-Motor Impairment, J of Neurovirol, 12, 178-189, 2006. 

Balaji S, Kalpana R, and Shapshak P, Comparative 3D modeling of HIV-1 virion infectivity factor, Bioinformation, 1, 290-309, 2006.

Vitiello B, K Goodkin, D Asthana, P Shapshak, J Atkinson, P Heseltine, E Eaton, R Heaton, F Wilkie, and W Lyman, Viral Load and Cognitive Performance Among HIV-Positive Persons with Cognitive-Motor Impairment, AIDS, 21, 1415–1422, 2007.

Z´arate S, SL Kosakovsky-Pond, P Shapshak, SDW Frost, A comparative study of methods for detecting sequence compartmentalization in HIV-1, Journal of Virology, 61, 6643–6651, 2007.

Kangueane Pandjassarame, Meena Kishore Sakharkar, Francesco Chiappelli, Paul Shapshak, Designing HIV Peptide Vaccines: Rhetoric or Reality for NeuroAIDS, Chapter for: “The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment” (Editors, K Goodkin MD PhD, A Verma MD, and P Shapshak PhD), ASM Press, in press, 2008.

Shapshak Paul, Alireza Minagar, Pandjassarame Kangueane, Simon Frost, Sergei L. Kosakovsky Pond, Selene Zarate, Elyse Singer, Deborah Commins, Anne De Groot, Miguel Quinones-Mateu, Ernest Terwilliger, Blood and Brain HIV Strain Variation, Chapter for: “The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment” (Editors, K Goodkin MD PhD, A Verma MD, and P Shapshak PhD), ASM Press, in press, 2008.

Minagar Alireza, Deborah Commins, J. Steven Alexander, Romy Hoque, Francesco Chiappelli, Elyse J. Singer, Behrooz Nikbin, Paul Shapshak, Diagnostics for NeuroAIDS: Present and Future, Molecular Diagnosis and Therapy, 12, 25-43, 2008.

Levine AJ, Singer EJ, P Shapshak, The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders, AIDS Behav, DOI 10.1007/s10461-008-9360-x, 2008.

Shapshak Paul, Hector E. Rodriguez, Rajarathinam Kayathri , Andrew Levine, Francesco Chiappelli, Alireza Minagar, ALZHEIMER’S DISEASE AND HIV ASSOCIATED DEMENTIA RELATED GENES. I. LOCATION AND FUNCTION, Bioinformation, 2008

Giunta Brian, Charurut Somboonwit, Tim Tellinghuisen, William K. Scott, Robert Duncan, Clyde McCoy, J Bryan Page, Jun Tan, Francisco Fernandez, and Paul Shapshak, Psychiatric Aspects of Hepatitis-C Infection, under review, 2008.

Shapshak Paul, Tim Tellinghuisen, William K. Scott, Robert Duncan,  Clyde McCoy, J Bryan Page, Charurut Somboonwit, Brian Giunta, and Francisco Fernandez, HCV and drug abuse, under review, 2008.

Fernandez F, Minagar A, Alekseeva N, and P. Shapshak, Neuropsychiatric aspects of prion disease, in Comprehensive Textbook of Psychiatry ed. by Sadock, Sadock, and Ruiz, in press, 2010.

Selected Book Chapters

Goodkin K, Shapshak P, Fujimura RK, Tuttle RS, Bradley WG, Yoshioka M, Nagano I, Xin KQ, Kumar A, Kumar M, Baldewicz TT, Maher KJ, Asthana D, and Fletcher MA, Immune function, brain, and HIV-1 infection, in Goodkin K, and A Visser (eds): Psychoneuroimmunology: Stress, Mental Disorders and Health, Washington, DC: American Psychiatric Association Press, Inc., 2000, pp. 243-316.

Goodkin K, Tuttle R, Blaney NT, Feaster DJ, Baldewicz TT, Uselman M, Nelson RH, Baum MK, Shapshak P, Kumar M, and Fletcher MA, Bereavement, Immunity, and the impact of Bereavement Support Groups in HIV-1 infection, in Goodkin K, and A Visser (eds): Psychoneuroimmunology: Stress, Mental Disorders and Health, Washington, DC: American Psychiatric Association Press, Inc., 2000, pp. 357-394.

Shapshak P, Alireza Minagar, Elda M. Duran, Fabiana Ziegler, Wade Davis, Raman Seth, and Toni Kazic, Gene Expression in HIV Associated Dementia, In: Inflammatory Disorders Of The Nervous System, Clinical Aspects, Pathogenesis, and Management, Edited by: Alireza Minagar, MD and J. Steven Alexander, PhD, Published by: Humana Press, Totowa, NJ, 2005.

Alireza Minagar, Paul Shapshak, and J. Steven Alexander, Pathogenesis of HIV associated Dementia and Multiple Sclerosis: role of microglia and astrocytes, in The Role of Glia in neurotoxicity, 2nd Edition, Edited by Michael Aschner and Lucio G. Costa, CRC Press (Boca Raton, Florida), 2005, Chapter 16, pp. 263-278.

Alireza Minagar and Paul Shapshak, HIV associated Dementia: Clinical features and pathogenesis, in NEURO-AIDS, Edited by Alireza Minagar & Paul Shapshak, Nova Science Publ (Hauppauge, New York), 2006, in press.

Shapshak Paul, Alireza Minagar, Pandjassarame Kangueane, Simon Frost, Sergei L. Kosakovsky Pond, Selene Zarate, Elyse Singer, Deborah Commins, Anne De Groot, Miguel Quinones-Mateu, Ernest Terwilliger, Blood and Brain HIV Strain Variation, Chapter for: “The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment” (Editors, K Goodkin MD PhD and P Shapshak PhD, in press, 2008, ASM Press.

Kangueane Pandjassarame, Meena Kishore Sakharkar, Francesco Chiappelli, Paul Shapshak, Designing HIV Peptide Vaccines: Rhetoric or Reality for NeuroAIDS, Chapter for: “The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment” (Editors, K Goodkin MD PhD and P Shapshak PhD, in press, 2008, ASM Press.

Fernandez F, Giunta B, Tan, J, and P. Shapshak, Neuropsychiatric aspects of prion disease, in Comprehensive Textbook of Psychiatry ed. by Sadock, Sadock, and Ruiz, in press, 2010.

Selected Abstracts

HV McCoy, SE Messiah, Z Yu, P Shapshak, J Gasana, Perpetrators, victims, and observers of violence: out-of-treatment chronic drug users vs. non-drug users, College on Problems of Drug Dependence, 62nd Annual Scientific Meeting, June17-22nd, Abstract 407, S143, San Juan, Puerto Rico, 2000.

Z Yu, HV McCoy, SE Messiah, P Shapshak, Perpetrators, victims, and observers of violence: gender differences in out-of-treatment chronic drug users vs. non-drug users, College on Problems of Drug Dependence, 62nd Annual Scientific Meeting, June17-22nd, Abstract 687, S242, San Juan, Puerto Rico, 2000.

P. Shapshak, K. Goodkin, A. Minagar, R. Fujimura, K. Crandall, E. Fenjves, R. Pastori, C. McCoy, B. Page, R. Duncan, R. Kuljis, W. Sheramata, W. Bradley, C. Petito, R. Ownby, and C. Eisdorfer. UNIFYING DEMENTIA HYPOTHESIS: MICROGLIA AND ASTROCYTES IN NEUROAIDS, ALZHEIMER’S DISEASE, AND MULTIPLE SCLEROSIS, 6th Poster Session of the Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 2/1/2000.

R. Fujimura, K. Goodkin, C.K. Petito, and P. Shapshak, HIV RNA and DNA load in NeuroAIDS brain, 6th Poster Session of the Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 2/1/2000.

P. Shapshak, R. Duncan, A. Minagar, K Goodkin, The predominant Role of IFN-? in the Neuropathogenesis of HIV-1 infection, Am Acad Neurol (AAN), Philadelphia, PA, May, 2001, Neurology, 56, Suppl. 3, S63.006, April, 2001.

A. Minagar, P. Shapshak, M Heyes, WA Sheramata, R. Fujimura, R. Ownby, K. Goodkin, and C. Eisdorfer, Microglia and astrocytes in NeuroAIDS, Alzheimer’s Disease, and Multiple Sclerosis, Miami Symposium in Biotechnology, Miami Beach, Florida, 2001.

R K Fujimura, I Khamis, P Shapshak, and K Goodkin, A Method for Regional Comparison of the Ratio of Regulatory mRNA to Structural RNA of HIV-1 in Infected Human Brain, American Society of Biochemistry and Molecular Biology, Orlando, FL, March 31st to April 4th, 2001.

P. Shapshak, R. Duncan, R. Kuljis, A. Minagar, P. Alcabes, R. Fujimura, R. Stewart, P. Rodriguez de la Vega, K. Goodkin, and C.K. Petito, Drug Abuse and AIDS Brain: Unexpected expression of neuronal Nitric Oxide Synthase, Interferon Gamma, TNF-alpha, and Il-4, College of Problems in Drug Dependence, Scottsdale, AZ, June 17th-21st, 2001.

J.B. Page, P. Shapshak, R. Duncan, E. Bandstra, and C. McCoy, Cocaine/Cocaethylene detection concordance: hair analysis vs. Urine Toxicology vs. Self-Report, College of Problems in Drug Dependence, Scottsdale, AZ, June 17th-21st, 2001.

C. McCoy, P. Shapshak, R. Duncan, F. Chiappelli, L. Metsch, and JB Page, Survival analysis and laboratory measures within a homogeneous cohort of Drug Abusers, College of Problems in Drug Dependence, Scottsdale, AZ, June 17th-21st, 2001.

P Shapshak, HIV evolution and NeuroAIDS, Gordon Conference on Bioinformatics, New Hampshire, August 2001.

P. Shapshak, R. Duncan, J.B. Page, New Real Time PCR method for ultrasensitive quantification of HIV RNA in n/s, paraphernalia, and wash waters from shooting galleries in Miami, College of Problems in Drug Dependence, Quebec, CN, June 15th-19th, 2002.

Torres-Munoz J, Shapshak P, Polavarapu G, Bowman M, and Petito CK, Gene expression in AIDS cerebral cortex, Int. Neurovirol. Meeting, Düsseldorf, Germany, June 11-19, 2002.

P Shapshak, Invited Chair: International Symposium on Bioinformatics & Cybernetics, Orlando, Florida, July 14-18th, 2002. (5 papers in chaired Symposium)

Shapshak Paul, Brain Gene Expression Studies In Dementia: Drug Abuse, HIV, and Amyloid, 3rd International Differential Gene Expression Symposium, Vanderbilt University School of Medicine, Oct 12-15th, 2002.

P Shapshak, Robert Duncan, Alireza Minagar, Raman Seth, and Toni Kazic, Gene expression in NeuroAIDS, International Neurovirology Society Conference, Baltimore, MD 2004

P Shapshak, Robert Duncan, Alireza Minagar, Karl Goodkin, Elda M. Duran, Avindra Nath, Jadwiga Turchan, Wade Davis, Raman Seth, and Toni Kazic, The use of Bioinformatics for Gene expression studies in NeuroAIDS, NIMH 10th Annual Human Brain Project Conference, April 26th - 27th 2004

P Shapshak, Robert Duncan, Alireza Minagar, Karl Goodkin, Elda M. Duran, Avindra Nath, Jadwiga Turchan, Wade Davis, Raman Seth, and Toni Kazic, Gene expression methods in NeuroAIDS, Harvard University Channing laboratories Statistics Society, May 2004.

P Shapshak, Invited Chair: International Symposium on Bioinformatics & Cybernetics, Orlando, Florida, July 14-18th, 2004  Brain gene expression (8 papers in chaired Symposium)

Eric Amaro and P. Shapshak, Apoptosis in astrocyte and neuroblastoma cell cultures: an in vitro model for Alzheimer’s disease, 2004 Annual Biomedical Research Conference for minority Students (ARBCMS), Hyatt Regency Dallas, Dallas, Texas, November 11th – 13th, 2004.

Apple Lewis and P. Shapshak, HIV Risk in Drug Abuse paraphernalia, 2004 Annual Biomedical Research Conference for minority Students (ARBCMS), Hyatt Regency Dallas, Dallas, Texas, November 11th – 13th, 2004.

Shapshak P, Goodkin KG, Duncan R, Nath A, Turchin J, Solveig AM Shapshak, Davis W, Kangueane P, Duran EM, Ziegler F, Minagar, Seth R, and Kazic T, Gene expression in human neurons in culture and brain. Use of differing Microarray and Bioinfoatmatics technologies, 11th SNIP Conference, April 6th -10th , 2005, Clearwater, Florida.

Shapshak P, Goodkin KG, Kazic T, Solveig AM Shapshak, and Nath A, Use of differing Microarray and bioinformatics technologies for gene expression in human neurons in culture and brain, 2005 NIDA International Forum: linking drug abuse and HIV/AIDS Research, June 17th -20th Orlando, FL 2005

Paul Shapshak, Robert Duncan, Karl Goodkin, Avindra Nath, Jadwiga Turchen, Alireza Minagar, Solveig AM Shapshak, Wade Davis, Raman Seth, and Toni Kazic, Neuron model for cocaine abuse and HIV infection of brain (NeuroAIDS): gene expression in cultured human neurons exposed to cocaine and HIV-1 proteins gp120 and tat, The Third Symposium on the Functional Genomics of Critical Illness and Injury, NIH, April 21st and 22nd, Bethesda, 2005.

Goodkin K, Asthana D, Shapshak P, Concha M, Khamis I, Lee D, Molina R, Frasca A, Zheng W, and O’Mellan S: Older Age and Immunological Measures among HIV-1 Infected Primary Spanish Speakers in the USA. In: Abstracts of 16th Annual Meeting of  the Amer Neuropsychiatric Association, 2/25/05-3/1/05, Miami Beach, FL, poster session II, poster #11.

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